About
When excessive amounts of fluids are secreted, for example in the event of diarrhea, Protein-AF will regulate and normalize the fluid transport across the intestinal wall and subsequently stop diarrhea. Hence the name Protein Antisecretory Factor.
Protein-AF will also bring down pressure caused by excessive amounts of fluids playing an important role for example in connection with Ménière’s disease.
When adding Protein-AF to the body a positive effect can normally be seen within a few hours. When stimulating the body's own production of Protein-AF a positive response can normally be seen after 10-15 days.
Background
The Swedish discovery of Protein-AF was the result of an antibiotic growth promoter ban in feed in 1986. A joint scientific project was initiated, combining expertise from veterinary medicine, microbiology, infectious diseases and immunology. Antibiotic growth promoters effectively prevented post-weaning diarrhea in piglets. The ban resulted in an increased prevalence of diarrhea which increased the deaths among piglets due to diarrhea. Protein-AF was discovered as a direct result of this research.
The first animal feed with Protein-AF was developed to stimulate the piglets’ own production of Protein-AF with the knowledge gained. The use of this new specialized feed proved very effective, resulting in a substantially lowered prevalence of diarrhea and significantly fewer deaths.
As the mechanisms involved are of a general physiological nature, researchers began to develop a similar cereal-based food for humans suffering from inflammatory bowel diseases, such as Ulcerative colitis and Crohn´s disease. This resulted in the first-ever approved food for special medical purposes (FSMP) in Sweden in 2000.
It has been shown that Protein-AF inhibits secretion caused, not only by cholera, but also by several other known toxins, i.e. E. coli, Campylobacter, Clostridium difficile and okadaic acid, the blue mussel toxin.
